Publications

Christoph H Emmerich, Lorena Martinez Gamboa, Martine C J Hofmann, Marc Bonin-Andresen, Olga Arbach,Pascal Schendel, Björn Gerlach, Katja Hempel, Anton Bespalov, Ulrich Dirnagl, Michael J Parnham. (2021) PMID: 33199880

Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. (2020) PMID: 31980337

Glimm AM, Sprenger LI, Haugen IK, Mansmann U, Hermann S, Häupl T, Hoff P, Burmester GR, Backhaus M, Le L, Ohrndorf S. Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period. Arthritis Res Ther. (2019) PMID: 31533820

Toldi G, Batel P, Baráth S, Szerémy P, Apjok A, Filkor K, Szántó S, Szűcs G, Szamosi S, Häupl T, Grützkau A, Szekanecz Z. Peripheral Lymphocyte Multidrug Resistance Activity as a Predictive Tool of Biological Therapeutic Response in Rheumatoid Arthritis. J Rheumatol. (2019) PMID: 30709954

Schulte-Wrede U, Sörensen T, Grün JR, Häupl T, Hirseland H, Steinbrich-Zöllner M, Wu P, Radbruch A, Poddubnyy D, Sieper J, Syrbe U, Grützkau A. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res Ther. (2018) PMID: 30157966

Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, Toupet K, Mausset-Bonnefont AL, Cren M, Robin M, Georgel P, Nehmar R, Taams L, Grün JR, Grützkau A, Häupl T, Pers YM, Jorgensen C, Duroux-Richard I, Courties G, Apparailly F. Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis. Theranostics. (2018) PMID: 30613275

Häupl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlmüller B, Schulze-Koops H, Burmester GR. Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark. Z Rheumatol. (2018) PMID: 29691690

Popadić D, Heßelbach K, Richter-Brockmann S, Kim GJ, Flemming S, Schmidt-Heck W, Häupl T, Bonin-Andresen M Dornhof R, Achten C, Günther S, Humar M, Merfort I. Gene expression profiling of human bronchial epithelial cells exposed to fine particulate matter (PM2.5) from biomass combustion. Toxicol Appl Pharmacol. (2018) PMID: 29596927

Schwedler C, Häupl T, Kalus U, Blanchard V, Burmester GR, Poddubnyy D, Hoppe B. Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity. Arthritis Res Ther. (2018) PMID: 29540200

Bonin-Andresen M, Smiljanovic B, Stuhlmüller B, Sörensen T, Grützkau A, Häupl T. Relevance of big data for molecular diagnostics. Z Rheumatol. (2018) PMID: 29520680

Burmester GR, Häupl T. Big data-also relevant in rheumatology? Z Rheumatol. (2018) PMID: 29619762

Smiljanovic B, Radzikowska A, Kuca-Warnawin E, Kurowska W, Grün JR, Stuhlmüller B, Bonin-Andresen M, Schulte-Wrede U, Sörensen T, Kyogoku C, Bruns A, Hermann S, Ohrndorf S, Aupperle K, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Maslinski W, Häupl T. Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint. Ann Rheum Dis. (2017) PMID: 29191820

Smiljanovic B, Bonin-Andresen M, Stuhlmüller B, Sörensen T, Grützkau A, Häupl T. Comment on "Single cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors." (2017) Link

Heßelbach K, Kim GJ, Flemming S, Häupl T, Bonin-Andresen M, Dornhof R, Günther S, Merfort I, Humar M. Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion. Epigenetics (2017) PMID: 28742980

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Casadonte R, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Sunitsch S, Tikhilov R, Morawietz L. 15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics. Pathol Res Pract. (2017) PMID: 28687159

Stich S, Loch A, Park SJ, Häupl T, Ringe J, Sittinger M. Characterization of single cell derived cultures of periosteal progenitor cells to ensure the cell quality for clinical application. PLoS One (2017) PMID: 28562645

Krenn V, Perino G, Rüther W, Krenn VT, Huber M, Hügle T, Najm A, Müller S, Boettner F, Pessler F, Waldstein W, Kriegsmann J, Häupl T, Wienert S, Krukemeyer MG, Sesselmann S, Tikhilov R, Morawietz L. Fifteen years of the histopathological synovitis score: Review and further developments of a diagnostic score. Z Rheumatol. (2017) PMID: 28470440

Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN. Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). J Cell Physiol. (2017) PMID: 27636101

Strauß R, Rose T, Flint SM, Klotsche J, Häupl T, Peck-Radosavljevic M, Yoshida T, Kyogoku C, Flechsig A, Becker AM, Dao KH, Radbruch A, Burmester GR, Lyons PA, Davis LS, Hiepe F, Grützkau A, Biesen R. Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options. J Mol Med. (2017) PMID: 28357476

Smiljanovic B, Radzikowska A, Kuca-Warnawin E, Kurowska W, Sörensen T, Stuhlmüller B, Bonin-Andresen M, Grün JR, Burmester GR, Radbruch A, Grützkau A, Maslinski W, Häupl T. Increased Turnover of Monocytes in Patients with Rheumatoid Arthritis Identified by Transcriptome and Cytometric Profiling. Ann Rheum Dis. (2017) Link

Duroux-Richard I, Roubert C, Ammari M, Présumey J, Grün JR, Häupl T, Grützkau A, Lecellier CH, Boitez V, Codogno P, Escoubet J, Pers YM, Jorgensen C, Apparailly F. miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics. Blood (2016) PMID: 27702798

Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Häupl T, Radbruch A, Sidiropoulos P, Kardassis D, Boumpas DT, Goulielmos GN. Differential Expression of miR-4520a Associated with Pyrin Mutations Suggesting a Role of Autophagy in Familial Mediterranean Fever (FMF). J Cell Physiol. (2016) PMID: 27636101

Stuhlmüller B, Mans K, Tandon N, Bonin-Andresen M, Smiljanovic B, Sörensen T, Schendel P, Martus P, Listing J, Detert J, Backhaus M, Neumann T, Winchester RJ, Burmester GR, Häupl T. Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis. Clin Immunol. (2016) PMID: 27570220

Strehl C, Schellmann S, Maurizi L, Hofmann-Amtenbrink M, Häupl T, Hofmann H, Buttgereit F, Gaber T. Effects of PVA-coated nanoparticles on human T helper cell activity. Toxicol Lett. (2016) PMID: 26774940

Smiljanovic B, Stuhlmüller B, Sörensen T, Bonin-Andresen M, Pade S, Backhaus M, Maslinski W, Burmester GR, Radbruch A, Grützkau A, Häupl T. Tissue- and Cell-Specific Transcriptomes Indicate Systemic Nature of RA and Revealed Combinations of Protein Biomarkers Relevant for Disease Characterisation in Serum. Ann Rheum Dis. (2016) Link

Sörensen T, Schulte-Wrede U, Hermann S, Grützkau A, Häupl T. immunoClust based analysis of cytometric profiles reveals immunophenotypic changes in synovial fluid compared to peripheral blood cells in rheumatoid arthritis. Ann Rheum Dis. (2016) Link

Stuhlmüller B, Skriner K, Häupl T. Biomarkers for prognosis of response to anti-TNF therapy of rheumatoid arthritis: Where do we stand? Z Rheumatol. (2015) PMID: 26347122

Strehl C, Gaber T, Maurizi L, Hahne M, Rauch R, Hoff P, Häupl T, Hofmann-Amtenbrink M, Poole AR, Hofmann H, Buttgereit F. Effects of PVA coated nanoparticles on human immune cells. Int J Nanomedicine. (2015) PMID: 26056442

Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. immunoClust-An automated analysis pipeline for the identification of immunophenotypic signatures in high-dimensional cytometric datasets. Cytometry A. (2015) PMID: 25850678

Smiljanovic B, Stuhlmüller B, Bonin-Andresen M, Pade S, Backhaus B, Burmester GR, Radbruch A, Grützkau A, Häupl T. The synovial tissue transcriptome reveals combinations of protein biomarkers for unambiguous identification of RA patients from synovial fluid and for quantification of disease activity in serum. Ann Rheum Dis. (2015) Link

Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. (2014) PMID: 25486906

Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B. Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction. J Renin Angiotensin Aldosterone Syst. (2014) PMID: 25155623

Ghannam K, Martinez-Gamboa L, Spengler L, Krause S, Smiljanovic B, Bonin M, Bhattarai S, Grützkau A, Burmester GR, Häupl T, Feist E. Upregulation of Immunoproteasome Subunits in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8 T-Cells and IFNγ. PLoS One (2014) PMID: 25098831

Kupfer P, Huber R, Weber M, Vlaic S, Häupl T, Koczan D, Guthke R, Kinne RW. Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics (2014) PMID: 24989895

Woetzel D, Huber R, Kupfer P, Pohlers D, Pfaff M, Driesch D, Häupl T, Koczan D, Stiehl P, Guthke R, Kinne RW. Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res Ther. (2014) PMID: 24690414

Stuhlmüller B, Häupl T, Burmester GR, Kinne RW. Prerequisites to Define and to Validate Therapy-Predicitive Blood Biomarkers. (2014) Link

Bonin M, Kokatjuhha J, Mans K, Grützkau A, Smiljanovic B, Sörensen T, Häupl T. Identification of geneexpression networks in different immunological states. Ann Rheum Dis. (2014) Link

Bonin M, Weidel L, Schendel P, Mans K, Flemming S, Grützkau A, Smiljanovic B, Sörensen T, Günther S, Häupl T. BioConPages - Comparison of DNA-Methylation and gene expression in different immune cells. Ann Rheum Dis. (2014) Link

Smiljanovic B, Stuhlmüller B, Maslinski W, Vogl T, Pade S, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Häupl T. From tissue- and cell-specific transcriptomes to candidate markers in rheumatoud arthritis. Ann Rheum Dis. (2014) Link

Ghannam K, Martinez-Gamboa L, Spengler L, Krause S, Smiljanovic B, Bonin M, Grützkau A, Burmester GR, Häupl T, Feist E. OP0131 Upregulation of Immunoproteasome Subunits PSMB8 and PSMB9 in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8+ T-Cells and IFN Gamma. Ann Rheum Dis. (2014) Link

Duroux-Richard I, Roubert C, Ammari M, Présumey J, Grün JR, Häupl T, Grützkau A, Lecellier CH, Jorgensen C, Apparailly F. MIR-125B controls mitochondrial functions and dynamics in monocytes. Ann Rheum Dis. (2014) Link

Kyogoku C, Smiljanovic B, Grün JR, Schulte-Wrede U, Alexander T, Biesen R, Hiepe F, Häupl T, Radbruch A, Grützkau A. T helper lymphocytes and monocytes as biosensors of type I interferon responses in viral infection and autoimmunity. Ann Rheum Dis. (2014) Link

Kyogoku C, Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Häupl T, Hiepe F, Alexander T, Radbruch A, Grützkau A. Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference? PLoS One. (2013) PMID: 24391825

Ullah M, Stich S, Häupl T, Eucker J, Sittinger M, Ringe J. Reverse differentiation as a gene filtering tool in genome expression profiling of adipogenesis for fat marker gene selection and their analysis. PLoS One. (2013) PMID: 23922792

Cobb JE, Plant D, Flynn E, Tadjeddine M, Dieudé P, Cornélis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Krintel SB, Ornbjerg LM, Hetland ML, Klareskog L, Häupl T, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Fitzgerald O, Veale D, Eyre S, Worthington J. Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLoS One. (2013) PMID: 23840476

Stuhlmüller B, Feist E, Häupl T, Burmester GR, Pipitone N. New aspects on the pathogenesis of myositis. Z Rheumatol. (2013) PMID: 23515563

Weix J, Häupl T, Raio L, Villiger PM, Förger F. The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis. Transl Res. (2013) PMID: 23507374

Bonin M, Flemming S, Günther S, Grützkau A, Häupl T. Combined Analysis of Epigenetic and Transcriptional Profiles in Different Immune Cells Identifies Hot Spots of Gene Regulation by DNA-Methylation. Ann Rheum Dis. (2013) Link

Häupl T, Sörensen T, Smiljanovic B, Bonin M, Grützkau A, Nikolaou C, Pandis I, Kollias G, Rowe A. Comparative Transcriptome Analysis of Human and Mouse Synovial Fibroblast Responses to TNF. Ann Rheum Dis. (2013) Link

Smiljanovic B, Stuhlmüller B, Pade S, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Häupl T. Synovial Tissue Transcriptome and Synovial Fluid Proteome have Stronger Discriminatory Power than Serum in Dissecting Inflammation in RA. Ann Rheum Dis. (2013) Link

Sörensen T, Schulte-Wrede U, Pade S, Hirseland H, Burmester GR, Radbruch A, Grützkau A, Häupl T. Automated and Standardised Analysis for High Dimensional Cytometric Data Provides New Options for Complex Cell-Associated Biomarker Screening. Ann Rheum Dis. (2013) Link

Kyogoku C, Smiljanovic B, Grün JR, Alexander T, Biesen R, Hiepe F, Häupl T, Radbruch A, Grützkau A. Cell-specific type I Interferon signatures in autoimmunity and viral infection: what makes the difference?. Ann Rheum Dis. (2013) Link

Smiljanovic B, Stuhlmüller B, Maslinski W, Burmester GR, Radbruch A, Grützkau A, Häupl T. Dissecting disease-specific differences in RA and OA by transcriptome analyses of synovial tissue, blood and bone marrow monocytes. Ann Rheum Dis. (2013) Link

Scherer HU, Burmester GR, Häupl T. Biomarkers and personalized medicine. Z Rheumatol. (2013) PMID: 23223890

Ebner F, Brandt C, Thiele P, Richter D, Schliesser U, Siffrin V, Schueler J, Stubbe T, Ellinghaus A, Meisel C, Sawitzki B, Nitsch R. Microglial activation milieu controls regulatory T cell responses. J Immunol. (2013) PMID: 24146044

Hassert R, Pagel M, Ming Z, Häupl T, Abel B, Braun K, Wiessler M, Beck-Sickinger AG. Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide. Bioconjug Chem. (2012) PMID: 22989005

Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A. The multifaceted balance of TNFα and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med. (2012) PMID: 22610275

Häupl T, Appel H, Backhaus M, Burkhardt H, Grünke M, Grützkau A, Hoppe B, Listing J, Ostendorf B, Rudwaleit M, Sieper J, Skapenko A, Skriner K, Sörensen T, Stuhlmüller B, Zink A, Schulze-Koops H, Burmester GR. Biomarkers in rheumatology: Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research. Z Rheumatol. (2012) PMID: 22546912

Kruger JP, Endres M, Neumann K, Stuhlmuller B, Morawietz L, Häupl T, Kaps C. Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis. J Orthop Surg Res. (2012) PMID: 22414301

Jullien N, Maudinet A, Leloutre B, Ringe J, Häupl T, Marie PJ. Downregulation of ErbB3 By Wnt3a Contributes to Wnt-induced osteoblast differentiation in mesenchymal cells. J Cell Biochem. (2012) PMID: 22274864

Hoppe B, Häupl T, Skapenko A, Ziemer S, Tauber R, Salama A, Schulze-Koops H, Burmester GR, Dörner T. Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation. Ann Rheum Dis. (2012) PMID: 22267327

Weix J, Förger F, Häupl T, Surbek D, Ostensen M, Villiger PM. Influence of pregnancy on the adipocytokine and PPAR pathways in peripheral blood mononuclear cells of healthy donors and RA patients. Arthritis Rheum. (2012) PMID: 22231457

Hoppe B, Burmester GR, Häupl T. Prothrombin 20210G>A genotype and C-reactive protein level. Blood. (2011) PMID: 22021457

Biesen R, Häupl T. DNA Microarrays. Z Rheumatol. (2011) PMID: 21956826

Menssen A, Häupl T, Sittinger M, Delorme B, Charbord P, Ringe J. Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development. BMC Genomics (2011) PMID: 21943323

Bal G, Kamhieh-Milz J, Futschik M, Häupl T, Salama A, Moldenhauer A. Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs). Cell Transplant. (2011) PMID: 21669038

Scheel T, Gursche A, Zacher J, Häupl T, Berek C. V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis. Arthritis Rheum. (2011) PMID: 20882667

Shahab-Osterloh S, Witte F, Hoffmann A, Winkel A, Laggies S, Neumann B, Seiffart V, Lindenmaier W, Gruber AD, Ringe J, Häupl T, Thorey F, Willbold E, Corbeau P, Gross G. Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions). Stem Cells. (2010) PMID: 20882636

Slansky E, Li J, Häupl T, Morawietz L, Krenn V, Pessler F. Quantitative determination of the diagnostic accuracy of the synovitis score and its components. Histopathology. (2010) PMID: 20840673

Endres M, Andreas K, Kalwitz G, Freymann U, Neumann K, Ringe J, Sittinger M, Häupl T, Kaps C. Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells. Osteoarthritis Cartilage. (2010) PMID: 20709179

Smiljanovic B, Grün JR, Steinbrich-Zöllner M, Stuhlmüller B, Häupl T, Burmester GR, Radbruch A, Grützkau A, Baumgrass R. Defining TNFα- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease. J Mol Med. (2010) PMID: 20640394

Kaltz N, Ringe J, Holzwarth C, Charbord P, Niemeyer M, Jacobs VR, Peschel C, Häupl T, Oostendorp RA. Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources. Exp Cell Res. (2010) PMID: 20599957

Hamidouche Z, Fromigué O, Ringe J, Häupl T, Marie PJ. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol. (2010) PMID: 20573191

Göhring AR, Lübke C, Andreas K, Kaps C, Häupl T, Pruss A, Perka C, Sittinger M, Ringe J. Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research. Biotechnol Prog. (2010) PMID: 20306542

Charbord P, Livne E, Gross G, Häupl T, Neves NM, Marie P, Bianco P, Jorgensen C. Human Bone Marrow Mesenchymal Stem Cells: A Systematic Reappraisal Via the Genostem Experience. Stem Cell Rev. (2010) PMID: 20198518

Scherer HU, van der Woude D, Ioan-Facsinay A, El Bannoudi H, Trouw LA, Koeleman CA, Wang J, Häupl T, Burmester GR, Deelder AM, Huizinga TW, Wuhrer M, Toes RE. Glycan profiling of anti-citrullinated protein antibodies (ACPA) isolated from human serum and synovial fluid. Arthritis Rheum. (2010) PMID: 20178128

Miraoui H, Ringe J, Häupl T, Marie PJ. Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. Hum Mol Genet. (2010) PMID: 20124286

Häupl T, Stuhlmüller B, Grützkau A, Radbruch A, Burmester GR. Does gene expression analysis inform us in rheumatoid arthritis? Ann Rheum Dis. (2010) PMID: 19995742

Stuhlmüller B, Häupl T, Hernandez MM, Grützkau A, Kuban RJ, Tandon N, Voss JW, Salfeld J, Kinne RW, Burmester GR. CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clin Pharmacol Ther. (2010) PMID: 20032971

Krüger JP, Endres M, Neumann K, Häupl T, Erggelet C, Kaps C. Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid. J Orthop Res. (2009) PMID: 20041492

Feron F, Delorme B, Nivet E, Gaillard J, Häupl T, Ringe J, Deveze A, Magnan J, Sohier J, Khrestchatisky M, Roman F, Charbord P, Sensebé L, Layrolle P. The human nose harbours a niche of olfactory ecto-mesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells Dev. (2009) PMID: 19905894

Gaber T, Häupl T, Sandig G, Tykwinska K, Fangradt M, Tschirschmann M, Hahne M, Dziurla R, Erekul K, Lautenbach M, Kolar P, Burmester GR, Buttgereit F. Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis. J Rheumatol. (2009) PMID: 19884271

Hamidouche Z, Fromigué O, Ringe J, Häupl T, Vaudin P, Pagès JC, Srouji S, Livne E, Marie PJ. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci USA. (2009) PMID: 19843692

Jakobs M, Häupl T, Krenn V, Guenther R. MMP- and FAP-mediated non-inflammation-related destruction of cartilage and bone in rheumatoid arthritis. Z Rheumatol. (2009) PMID: 19593575

Delorme B, Ringe J, Pontikoglou C, Gaillard J, Langonné A, Sensebé L, Noël D, Jorgensen C, Häupl T, Charbord P. Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity. Stem Cells. (2009) PMID: 19418444

Stich S, Haag M, Häupl T, Sezer O, Notter M, Kaps C, Sittinger M, Ringe J. Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12. Cell Tissue Res. (2009) PMID: 19296133

Menssen A, Edinger G, Grün JR, Haase U, Baumgrass R, Grützkau A, Radbruch A, Burmester GR, Häupl T. SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data. BMC Genomics. (2009) PMID: 19265543

Mrugala D, Dossat N, Ringe J, Delorme B, Coffy A, Bony C, Charbord P, Häupl T, Daures JP, Noël D, Jorgensen C. Gene expression profile of multipotent mesenchymal stromal cells: Identification of pathways common to TGFbeta3/BMP2-induced chondrogenesis. Cloning Stem Cells. (2009) PMID: 19196040

Andreas K, Häupl T, Lübke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C. Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. (2009) PMID: 19192274

Kalwitz G, Endres M, Neumann K, Skriner K, Ringe J, Sezer O, Sittinger M, Häupl T, Kaps C. Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. Int J Biochem Cell Biol. (2009) PMID: 18707017

Hoppe B, Häupl T, Egerer K, Gruber R, Kiesewetter H, Salama A, Burmester GR, Dörner T. Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. Ann Rheum Dis. (2009) PMID: 18633125

Bramlage CP, Kaps C, Ungethüm U, Bramlage P, Koziolek M, Wessels J, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR, Häupl T. Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium. Scand J Rheumatol. (2008) PMID: 18830904

Häupl T, Østensen M, Grützkau A, Radbruch A, Burmester GR, Villiger PM. Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity. Arthritis Rheum. (2008) PMID: 18821679

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med. (2008) PMID: 18663125

Kaltz N, Funari A, Hippauf S, Delorme B, Noël D, Riminucci M, Jacobs VR, Häupl T, Jorgensen C, Charbord P, Peschel C, Bianco P, Oostendorp RA. In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. Stem Cells. (2008) PMID: 18617685

Häupl T, Østensen M, Grützkau A, Burmester GR, Villiger PM. Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures. Rheumatology (Oxford). (2008) PMID: 18504279

Tripmacher R, Gaber T, Dziurla R, Häupl T, Erekul K, Grützkau A, Tschirschmann M, Scheffold A, Radbruch A, Burmester GR, Buttgereit F. Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production. Eur J Immunol. (2008) PMID: 18493983

Ringe J, Leinhase I, Stich S, Loch A, Neumann K, Haisch A, Häupl T, Manz R, Kaps C, Sittinger M. Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering. J Tissue Eng Regen Med. (2008)PMID: 18383554

Biesen R, Demir C, Barkhudarova F, Grün JR, Steinbrich-Zöllner M, Backhaus M, Häupl T, Rudwaleit M, Riemekasten G, Radbruch A, Hiepe F, Burmester GR, Grützkau A. Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum. (2008) PMID: 18383365

Guenther R, Krenn V, Häupl T. Expression analyses for rheumatoid arthritis. Z Rheumatol. (2008) PMID: 18210133

Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M. Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther. (2008) PMID: 18205922

Delorme B, Ringe J, Gallay N, Le Vern Y, Kerboeuf D, Jorgensen C, Rosset P, Sensebé L, Layrolle P, Häupl T, Charbord P. Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood. (2008) PMID: 18086871

Kastrinaki MC, Sidiropoulos P, Roche S, Ringe J, Lehmann S, Kritikos H, Vlahava VM, Delorme B, Eliopoulos GD, Jorgensen C, Charbord P, Häupl T, Boumpas DT, Papadaki HA. Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis. Ann Rheum Dis. (2008) PMID: 17921184

Grützkau A, Grün JR, Häupl T, Burmester GR, Radbruch A. Gene expression in inflammatory rheumatic diseases. Dtsch Med Wochenschr. (2007) PMID: 17823881

Endres M, Neumann K, Häupl T, Erggelet C, Ringe J, Sittinger M, Kaps C. Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow. J Orthop Res. (2007) PMID: 17549723

Häupl T, Burmester GR, Giannitsis E, Rohrlach T, Spanuth E, Parsch H, Brune K. N-terminal prohormone brain natriuretic peptide: a biomarker for detecting cardiovascular risks in patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis. (2007) PMID: 17513573

Neumann K, Endres M, Ringe J, Flath B, Manz R, Häupl T, Sittinger M, Kaps C. BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture. J Cell Biochem. (2007) PMID: 17497692

Häupl T, Yahyawi M, Lübke C, Ringe J, Rohrlach T, Burmester GR, Sittinger M, Kaps C. Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. (2007) PMID: 17379860

Ringe J, Häupl T, Sittinger M. Future of tissue engineering in rheumatic diseases. Expert Opin Biol Ther. (2007) PMID: 17309320

Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Häupl T. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology. (2006) PMID: 16978198

Krenn V, Morawietz L, König B, Otto M, Kriegsmann J, Köpenik A, Böhme T, Häupl T. Low-grade-/high-grade-synovitis: synovitis-score as a gold standard?. Orthopade. (2006) PMID: 16819616

Mahr S, Burmester GR, Hilke D, Göbel U, Grützkau A, Häupl T, Hauschild M, Koczan D, Krenn V, Neidel J, Perka C, Radbruch A, Thiesen HJ, Müller B. Cis- and trans-acting gene regulation is associated with osteoarthritis. Am J Hum Genet. (2006) PMID: 16642435

Kaps C, Frauenschuh S, Endres M, Ringe J, Haisch A, Lauber J, Buer J, Krenn V, Häupl T, Burmester GR, Sittinger M. Gene expression profiling of human articular cartilage grafts generated by tissue engineering. Biomaterials. (2006) PMID: 16545449

Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. (2006) PMID: 16542506

Hoppe B, Häupl T, Gruber R, Kiesewetter H, Burmester GR, Salama A, Dörner T. Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study. Arthritis Res Ther. (2006) PMID: 16469113

Djouad F, Bony C, Häupl T, Uzé G, Lahlou N, Louis-Plence P, Apparailly F, Canovas F, Rème T, Sany J, Jorgensen C, Noël D. Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Arthritis Res Ther. (2005) PMID: 16277684

Bramlage CP, Häupl T, Kaps C, Bramlage P, Müller GA, Strutz F. Bone morphogenetic proteins in the skeletal system. Z Rheumatol. (2005) PMID: 16184350

Krenn V, Morawietz L, Burmester GR, Häupl T. Synovialitis score: histopathological grading system for chronic rheumatic and non-rheumatic synovialitis. Z Rheumatol. (2005) PMID: 15965818

Häupl T, Grützkau A, Grün JR, Bonin M, Stuhlmüller B, Rohrlach T, Kaps C, Rudwaleit M, Morawietz L, Gursche A, Zacher J, Krenn V, Burmester GR, Radbruch A. Dissection of expression profiles into functional components: a strategy to identify the pieces in the puzzle of systems biology. 19th NGFN Meeting (2005) Link

Skriner K, Konthur Z, Häupl T, Adolph K, Burguera G, Sternjak A, Förster A, Lehrach H, Hollidt JM, Burmester GR. Immunomics in inflammatory rheumatic diseases. 19th NGFN Meeting (2005) Link

Podtschaske M, Hoefer T, Lamottke B, Niesner U, Grün JR, Häupl T, Burmester GR, Radbruch A, Baumgrass R. Immediate early gene expression of Il-2 producing and nonproducing cells reflects the cell fate decision of stimulated human T cells. 19th NGFN Meeting (2005) Link

Grützkau A, Grün JR, Stuhlmüller B, Rudwaleit M, Sieper J, Gerstmayer B, Baumgrass R, Mahr S, Müller-Hilke B, Janitz M, Burmester GR, Häupl T, Radbruch A. The transcriptome of monocytes reveals disease-specific alterations in chronic inflammatory rheumatic diseases. 19th NGFN Meeting (2005) Link

Chakraborty T, Ruocco I, Hossain H, Adler H, Autenrieth I, Bohn E, Burmester GR, Dingel S, Ehlers S, Häupl T, Hoffmann WH, Horstmann R, Jacobsen M, Keller C, Lang R, Meyer CG, Radbruch A, Schubert U, Seeger W, Wagner H. Springende Erreger und Entzündungen ohne Infektion - Das Infektions- und Entzündungsnetzwerk im Nationalen Genomforschungsnetz (NGFN) / übertragbare Krankheiten mit dramatischen Folgen/Analyse von Entzündungsreaktionen für neue Heilungsstrategien. GenomExpress (2005) Link

Burmester GR, Häupl T. Strategies using functional genomics in rheumatic diseases. Autoimmun Rev. (2004) PMID: 15546803

Kaps C, Hoffmann A, Zilberman Y, Pelled G, Häupl T, Sittinger M, Burmester G, Gazit D, Gross G. Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2). Biofactors. (2004) PMID: 15322331

Krenn V, Petersen I, Häupl T, Koepenik A, Blind C, Dietel M, Konthur Z, Skriner K. Array technology and proteomics in autoimmune diseases. Pathol Res Pract. (2004) PMID: 15237918

Häupl T, Krenn V, Stuhlmüller B, Radbruch A, Burmester GR. Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies. Arthritis Res Ther. (2004) PMID: 15225356

Sopov I, Sörensen T, Magbagbeolu M, Jansen L, Beer K, Kühne-Heid R, Kirchmayr R, Schneider A, Dürst M. Detection of cancer-related gene expression profiles in severe cervical neoplasia. Int J Cancer. (2004) PMID: 15305373

Ringe J, Häupl T, Sittinger M. Mesenchymal stem cells for tissue engineering of bone and cartilage. Med Klin (Munich). (2003) PMID: 14992201

Schmitt B, Ringe J, Häupl T, Notter M, Manz R, Burmester GR, Sittinger M, Kaps C. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation. (2003) PMID: 14686954

Häupl T, Ringe J, Erggelet C, Kaps C, Burmester GR, Sittinger M. Tissue engineering: chances and challenges for application in rheumatic diseases. Z Rheumatol. (2003) PMID: 14648092

Häupl T, Burmester GR, Stuhlmüller B. New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases. Z Rheumatol. (2002) PMID: 12426845

Kaps C, Loch A, Haisch A, Smolian H, Burmester GR, Häupl T, Sittinger M. Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes. Med Biol Eng Comput. (2002) PMID: 12227637

Krenn V, Morawietz L, Häupl T, Neidel J, Petersen I, König A. Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology. Pathol Res Pract. (2002) PMID: 12092767

Riemekasten G, Ziemer S, Häupl T, Melzer C, Loddenkemper K, Hauptmann S, Burmester GR, Hiepe F. Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. Lupus. (2002) PMID: 12043882

Ringe J, Kaps C, Schmitt B, Büscher K, Bartel J, Smolian H, Schultz O, Burmester GR, Häupl T, Sittinger M. Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages. Cell Tissue Res. (2002) PMID: 11904768

Kaps C, Bramlage C, Smolian H, Haisch A, Ungethüm U, Burmester GR, Sittinger M, Gross G, Häupl T. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum. (2002) PMID: 11817587

Rosen O, Thiel A, Massenkeil G, Hiepe F, Häupl T, Radtke H, Burmester GR, Gromnica-Ihle E, Radbruch A, Arnold R. Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells. Arthritis Res. (2000) PMID: 11056673

Sittinger M, Perka C, Schultz O, Häupl T, Burmester GR. Joint cartilage regeneration by tissue engineering. Z Rheumatol. (1999) PMID: 10441839

Redlich A, Perka C, Schultz O, Spitzer R, Häupl T, Burmester GR, Sittinger M. Bone engineering on the basis of periosteal cells cultured in polymer fleeces. J Mater Sci Mater Med. (1999) PMID: 15347948

Riemekasten G, Marell J, Trebeljahr G, Klein R, Hausdorf G, Häupl T, Schneider-Mergener J, Burmester GR, Hiepe F. A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. J Clin Invest. (1998) PMID: 9710444

Keyszer G, Redlich A, Häupl T, Zacher J, Sparmann M, Engethüm U, Gay S, Burmester GR. Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. Arthritis Rheum. (1998) PMID: 9704635

Seki T, Selby J, Häupl T, Winchester R. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. (1998) PMID: 9704633

Häupl T, Landgraf S, Netusil P, Biller N, Capiau C, Desmons P, Hauser P, Burmester GR. Activation of monocytes by three OspA vaccine candidates: lipoprotein OspA is a potent stimulator of monokines. FEMS Immunol Med Microbiol. (1997) PMID: 9322065

Rittig MG, Häupl T, Krause A, Kressel M, Groscurth P, Burmester GR. Borrelia burgdorferi-induced ultrastructural alterations in human phagocytes: a clue to pathogenicity? J Pathol. (1994) PMID: 7931847

Rittig MG, Häupl T, Burmester GR. Coiling phagocytosis: a way for MHC class I presentation of bacterial antigens? Int Arch Allergy Immunol. (1994) PMID: 8260849

Häupl T, Hahn G, Rittig M, Krause A, Schoerner C, Schönherr U, Kalden JR, Burmester GR. Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis Rheum. (1993) PMID: 8240439

Rittig MG, Krause A, Häupl T, Schaible UE, Modolell M, Kramer MD, Lütjen-Drecoll E, Simon MM, Burmester GR. Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi. Infect Immun. (1992) PMID: 1398932

Häupl T, Burmester GR. Clinical aspects, diagnosis and therapy of Lyme borreliosis. Z Arztl Fortbild (Jena). (1992) PMID: 1546489

Häupl T, Burmester GR, Hahn G, Feige U, Rordorf-Adam C, Kalden JR. Differential immunological response of patients with rheumatoid arthritis towards two different Epstein-Barr virus strains: inhibition of interleukin-1 release by the B95-8, but not the P3HR-1 virus strain. Rheumatol Int. (1989) PMID: 2558410